Abstract
Current neurodegenerative research lacks an integrated benchtop engine capable of simulating the mechanical, electrokinetic, and acoustic parameters required to clear proteinaceous aggregates (Tau tangles, Amyloid-$\beta$ oligomers, and $\alpha$-Synuclein fibrils) from dense extracellular matrices.
CNCS-1.0 fills this gap by coupling acoustic streaming, resonant microbubble shear, amplitude-modulated radiofrequency destabilization, and electrokinetic transport into a single, temperature-locked PEEK-1000 micro-vortex chamber. The system reduces simulated Interstitial Fluid Pressure (IFP) from $25\text{ mmHg}$ down to $\le 6\text{ mmHg}$ in tissue phantoms while driving unidirectional magnetophoretic and acoustic aggregate clearance—all without exceeding a $\Delta T$ of $+0.4^\circ\text{C}$ in the biological matrix.
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Recommended Citation
Caldwell, Michael Victor Mr., "CALDWELL NEURO-CLEARANCE SUPER-ENGINE (CNCS-1.0) A Unified Multi-Physics Research Reactor for Non-Thermal clearance of Neuro-Toxic Aggregates in Synthetic Tissue Phantoms", Technical Disclosure Commons, ()
https://www.tdcommons.org/dpubs_series/11692