Abstract
The Integrated Zero-Heat Neural Interface (IZHNI) is a conceptual TRL-4 engineering architecture defining a coupled thermal–fluidic–mechanical system designed to manage localized electronic heat loads (~250 mW) in extreme spatial constraint environments relevant to neural interface technologies.
This disclosure does not describe a medical device or implantable system, but rather a simulation-ready and benchtop-testable thermal management framework intended for independent validation in non-biological environments.
The system integrates three coupled subsystems: (1) anisotropic thermal biasing layers that preferentially direct heat flow, (2) parallel microfluidic heat extraction channels operating in a low-Reynolds chaotic advection regime, and (3) a mechanically compliant substrate designed to reduce strain transfer in soft-tissue-mimicking environments.
The architecture is defined entirely through bounded physical parameters, including thermal resistance constraints, fluidic pressure limits, mechanical strain thresholds, and explicit multiphysics coupling conditions. A complete CFD-ready parameter set, failure mode analysis, and benchtop validation protocol are included.
Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.
Recommended Citation
Caldwell, Michael Victor Mr., "Integrated Zero-Heat Neural Interface (IZHNI): TRL-4 Multiphysics Thermal–Fluidic–Mechanical Architecture for Low-Power Neural Interface Heat Management", Technical Disclosure Commons, ()
https://www.tdcommons.org/dpubs_series/10013