Abstract
This Vortex-Inertial Magnetic Blood-Plasma Purifier disclosure describes a continuous-flow, non-clogging system for the selective enrichment and extraction of biomarkers from blood plasma. The device integrates inertial microfluidic separation, magnetophoretic transport, and an open-cell gyroid lattice trapping mechanism into a unified architecture. Whole blood is first processed through a spiral microfluidic manifold operating in the Dean-flow regime to achieve passive separation of cellular components, producing a plasma stream with reduced hematocrit. Target biomarkers are captured using aptamer-functionalized superparamagnetic nanoparticles and transported via magnetophoretic drift within a controlled magnetic field gradient. These particles are subsequently immobilized within a high-surface-area gyroid lattice incorporating localized magnetic field gradients. Regeneration is achieved through pulsed ultrasonic actuation, enabling mechanical release of captured particles without chemical stripping. The system is designed to operate within defined flow, thermal, and acoustic constraints to minimize fouling and biomolecular degradation. This open-hardware platform provides a reusable, scalable alternative to conventional filtration and chromatographic methods for diagnostic and therapeutic applications.
Creative Commons License
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Recommended Citation
Caldwell, Michael Victor Mr., "Vortex-Inertial Magnetic Blood-Plasma Purifier", Technical Disclosure Commons, ()
https://www.tdcommons.org/dpubs_series/10012