Abstract

CVTCC-2.0 is a proposed open-hardware research and prototype platform for determining whether the dynamic physiological response to a controlled, small, externally applied thermal perturbation contains measurable information about vascular, neurovascular, autonomic, thermoregulatory, or cranio-venous physiological state.

The system does not assume that temperature is a surrogate for blood flow.

Instead, CVTCC-2.0 deliberately applies a known thermal input and records the resulting response across multiple independent measurement channels.

The central research concept is:

Known thermal input → measured thermal response → vascular response → autonomic response → cardiac/respiratory phase relationship → independent vascular reference → artifact rejection → reproducible response signature. opens research possibilities beyond NASA, including:

  • Neurovascular research — cerebral blood-flow regulation and neurovascular coupling.

  • Dementia/MCI research — whether vascular/autonomic response dynamics differ between groups.

  • Autonomic disorders — response delay, amplitude, asymmetry and recovery following controlled thermal challenges.

  • Parkinson's/MSA research — thermoregulatory and autonomic-response characterization.

  • Stroke/TBI research — investigating altered vascular regulation and recovery dynamics.

  • Peripheral vascular research — comparing regional vascular responses.

  • Vascular-access research — potentially investigating dynamic thermal/flow relationships, where appropriate.

  • Spaceflight physiology — thermoregulation and altered vascular behavior in microgravity analogs.

  • Healthy aging research — establishing normal response distributions before studying disease populations.

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

Download

Share

COinS