Abstract

The Caldwell Adaptive Ocular Transport Discovery Platform (AOTDP-1.0) is an open-hardware experimental research platform designed to investigate, compare, and optimize candidate non-invasive ocular transport mechanisms using standardized laboratory phantom eye models.

The platform does not claim to provide a clinically validated drug-delivery method. Instead, it addresses a fundamental engineering challenge:

How can researchers objectively evaluate competing physical mechanisms for transporting therapeutic agents toward posterior ocular regions without invasive injection approaches?

AOTDP-1.0 provides a modular multi-physics test environment where researchers can independently test and compare:

  • acoustic transport methods,

  • controlled micro-pressure gradients,

  • electromagnetic-assisted approaches,

  • optical stimulation concepts,

  • fluidic transport mechanisms,

  • mechanical interface structures,

  • biomimetic surface architectures,

  • AI-assisted optimization strategies,

  • and hybrid combinations.

The central innovation is not a single transport method.

The innovation is the creation of a common experimental discovery platform where multiple approaches can be measured under identical conditions.

The system transforms posterior ocular transport research from isolated invention attempts into a structured engineering optimization process.

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

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