Abstract

The Ocular Neuro‑Restoration System (ONRS) is a non‑invasive, wearable ultrasound platform designed to deliver neuroprotective and vascular‑restorative therapeutics to the retina, optic nerve head, and posterior eye without injections. The system uses low‑intensity focused ultrasound (LIFU), vortex‑phase acoustic fields, microbubble‑enhanced sonoporation, and microfluidic tear‑exchange diagnostics to overcome the anatomical barriers that normally block ocular drug delivery.

A CMUT phased array generates controlled acoustic streaming and reversible tight‑junction modulation, enabling 10–50× enhanced penetration of small molecules and biologics, consistent with published evidence that ultrasound increases ocular permeability and drug transport .

A PDMS microfluidic gel‑refresh system maintains uniform coupling and eliminates stagnation zones, while a tear‑film biomarker module uses capillary filtration and concentration to quantify neurodegeneration markers such as NFL, tau, and α‑synuclein.

Triple‑redundant safety interlocks, thermal buffering, and an acoustic “zero‑energy shadow zone” protect the lens and retina, consistent with safety limits described in your uploaded document (“ultrasonic acoustic intensity limits… to completely prevent thermal or mechanical damage”) and with published safety profiles of ocular ultrasound .

This dossier provides a complete, fabrication‑ready architecture for ONRS, enabling real‑world prototyping, porcine testing, and eventual clinical translation.

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Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

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