Abstract
The Caldwell Adaptive Plasma Conditioning & Sensing System (CAPCS v4.0) is a next‑generation, fully autonomous microfluidic biosensing platform designed for real‑world plasma analysis under variable biological, thermal, and mechanical conditions. CAPCS integrates differential quartz crystal microbalance (QCM) sensing, surface acoustic wave (SAW) focusing, adaptive closed‑loop control, predictive fouling detection, dynamic thermal stabilization, and hybrid inertial–acoustic cell removal into a single disposable cartridge.
Unlike traditional biosensor concepts that rely on static assumptions, CAPCS v4.0 continuously adapts to fouling, drift, clogging, viscosity changes, hematocrit variability, and thermal fluctuations. Every major failure mode is paired with a dedicated countermeasure. The system uses dual‑QCM architecture, optical scatter correlation, periodic acoustic detuning, flow‑adaptive microchannel conditioning, and real‑time thermal feedback to maintain stable sensing conditions.
This disclosure is released fully open, with no withheld details, for global public use, research, and development.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Recommended Citation
Caldwell, Michael Victor Mr., "Caldwell Adaptive Plasma Conditioning & Sensing System (CAPCS v4.0)", Technical Disclosure Commons, (May 18, 2026)
https://www.tdcommons.org/dpubs_series/10155