Abstract
The VLSE-1 (Vascular Leak Stabilization Envelope) is a conceptual laboratory-only extracorporeal flow-conditioning and staged adsorption cartridge architecture intended for benchtop investigation within ECMO-style circulation loops.
The proposed system is designed to explore whether ultra-low-shear blood-flow conditioning combined with progressive inflammatory adsorption zones can produce more stable fluidic behavior than conventional abrupt high-resistance adsorption cartridges.
The architecture integrates:
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low-shear inertial flow conditioning,
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staged adsorption regions,
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clot-localization geometry,
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passive thermal stabilization,
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microbubble separation,
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passive zero-energy bypass logic,
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ECMO-compatible flow-path concepts,
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progressive saturation behavior.
Unlike aggressive purification systems, the VLSE-1 concept prioritizes:
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flow continuity,
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hemocompatibility,
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pressure stability,
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predictable degradation behavior,
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preservation of formed fluid elements.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Recommended Citation
Caldwell, Michael Victor Mr., "GCI-302 — Vascular Leak Stabilization Envelope (VLSE-1)", Technical Disclosure Commons, (May 13, 2026)
https://www.tdcommons.org/dpubs_series/10093