Abstract

(respectallamericans@gmail.com) Michael Victor Caldwell Mr., GCI

Abstract:

GCI Platform #16+18: Two-Step Extracorporeal Blood Conditioning System for Microplastic and Plaque-Like Aggregate Reduction (CERN-OHL-P) This disclosure describes a two-step extracorporeal blood-conditioning platform for reducing both microplastic-particle load and amyloid-like plaque aggregates in blood-like fluids, intended as a pre-treatment strategy for neuro-focused therapies such as focused-ultrasound (FUS) dementia-targeting protocols. The platform consists of:

Step-1: GCI #16 v2.x - Acoustophoresis cartridge that removes circulating microplastics (1-100 μm, PET/BPA-like) via standing-wave ultrasound (1-10 MHz), vortex-J-groove mixing, and EchoGrid-style channel stacks operating at 5-10 mL/min. Bench-top tests show >90% capture efficiency of fluorescent polystyrene beads in blood-analog while preserving >95% cell recovery and hemolysis < 2% (ISO 10993), with projected BOM of ~$500/unit at 100-unit scale.

Step-2: GCI #18 - Affinity-filtration cartridge that removes amyloid-like aggregates, fibrin-derived microclots, and neuro-relevant vascular debris using low-pressure-drop micro-mesh with chemically functionalized surfaces (amyloid-specific antibodies, heparin-like coatings, rGO-enhanced adsorption sites). Designed for modular stacking after GCI #16 v2.x in closed-loop circuits.

Both modules maintain hemolysis < 2% (ISO 10993) and are released under CERN-OHL-P v2.0 as open-hardware prior-art concepts for research, humanitarian, or future-regulated-medical-device development. Open-Concept Declaration: All GCI-series disclosures by Michael Victor Caldwell are online-only technical concepts serving as defensive publications in the public domain - no commercial intent or confidential claims asserted.

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Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

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