Improved process for the preparation of 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-6- [(2-hydroxyethoxy)carbamoyl]-1-methyl-1H-benzimidazol-3-ium or a salt thereof

Inventor(s)

MSN Laboratories Private Limited, R&D Center; Srinivasan Thirumalai Rajan, Ghojala Venkat Reddy, Uppalanchi Srinivas, Manda Ananth Reddy, Revu Satyanarayana, Nomula Sathaiah, Rayavarapu Srinuvasa raoFollow

Abstract

Abstract:

The present invention relates to an improved process for the preparation of 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-6-[(2-hydroxyethoxy)carbamoyl]-1-methyl-1H benzimidazol-3-ium or a salt thereof, which is referred to as Selumetinib and represented by the following structural formulae,

Formula-1

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

Recommended Citation

MSN Laboratories Private Limited, R&D Center; Srinivasan Thirumalai Rajan, Ghojala Venkat Reddy, Uppalanchi Srinivas, Manda Ananth Reddy, Revu Satyanarayana, Nomula Sathaiah, Rayavarapu Srinuvasa rao, "Improved process for the preparation of 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-6- [(2-hydroxyethoxy)carbamoyl]-1-methyl-1H-benzimidazol-3-ium or a salt thereof", Technical Disclosure Commons, (September 22, 2025)
https://www.tdcommons.org/dpubs_series/8614