Crystalline forms of N-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-N’-(4­ fluorophenyl) cyclopropane-1,1-dicarboxamide salts and process for its preparation thereof

Inventor(s)

MSN Laboratories Private Limited, R&D Center; Srinivasan Thirumalai Rajan, Sajja Eswaraiah, Vijayavitthal T. Mathad, Saladi Venkata Narasayya, Kammari Bal RajuFollow

Abstract

Abstract:

The present invention relates to crystalline forms of N-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-N’-(4­fluorophenyl)cyclopropane-1,1-dicarboxamide maleate represented by the following structural formula-1a, which is referred to as Cabozantinib maleate.

Formula-1a

The present invention also relates to crystalline form of N-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-N’-(4­fluorophenyl)cyclopropane-1,1-dicarboxamide fumarate represented by the following structural formula-1b, which is referred to as Cabozantinib fumarate.

Formula-1b

Creative Commons License

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Recommended Citation

MSN Laboratories Private Limited, R&D Center; Srinivasan Thirumalai Rajan, Sajja Eswaraiah, Vijayavitthal T. Mathad, Saladi Venkata Narasayya, Kammari Bal Raju, "Crystalline forms of N-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-N’-(4­ fluorophenyl) cyclopropane-1,1-dicarboxamide salts and process for its preparation thereof", Technical Disclosure Commons, (November 07, 2023)
https://www.tdcommons.org/dpubs_series/6400