Abstract
This report is related to a process using a ketoreductase enzyme for the preparation of enantiomerically pure (R)‑1-(2-chlorophenyl)-2-(2H-tetrazol-2-yl)ethan-1-ol, an intermediate to one of the APIs, used for CNS mediated diseases, [(1R)-1-(2-Chlorophenyl)-2-(tetrazol-2-yl) ethyl] carbamate.
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Recommended Citation
"An improved biocatalytic route to access (R)-1-(2-chlorophenyl)-2-(2H-tetrazol-2-yl)ethan-1-ol, a precursor to [(1R)-1-(2-Chlorophenyl)-2-(tetrazol-2-yl) ethyl] carbamate", Technical Disclosure Commons, (August 02, 2023)
https://www.tdcommons.org/dpubs_series/6103