Process for the preparation of (S)-methyl (1-aminopropan-2-yl)carbamate hydrochloride

Inventor(s)

MSN Laboratories Private Limited, R&D Center; Srinivasan Thirumalai Rajan; Sajja Eswaraiah; Vijayavitthal T. Mathad; Nagunuri Ganapathi CharyFollow

Abstract

Process for the preparation of (S)-methyl (1-aminopropan-2-yl)carbamate hydrochloride of formula-1, which is represented by the following structural formula:

which is key intermediate for the preparation of Encorafenib, which is chemically known as methyl N-{(2S)-1-[(4-{3-[5-chloro-2-fluoro-3­(methanesulfonamido)phenyl]-1-(propan-2-yl)-1H-pyrazol-4-yl}pyrimidin-2-yl)amino]propan-2­yl}carbamate.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

Recommended Citation

MSN Laboratories Private Limited, R&D Center; Srinivasan Thirumalai Rajan; Sajja Eswaraiah; Vijayavitthal T. Mathad; Nagunuri Ganapathi Chary, "Process for the preparation of (S)-methyl (1-aminopropan-2-yl)carbamate hydrochloride", Technical Disclosure Commons, (August 03, 2021)
https://www.tdcommons.org/dpubs_series/4519