Abstract
The present disclosure describes an improved process for the preparation of suzetrigine or a pharmaceutically acceptable salt thereof. The process involves the preparation of methyl 4-aminopyridine-2-carboxylate, followed by its coupling with (2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoro methyl)tetrahydrofuran-2-carboxylic acid. The resulting ester intermediate is converted to suzetrigine by treatment with ammonia in an alcoholic solvent. A further purification step using acetone and isopropyl alcohol affords the desired product.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Recommended Citation
Anonymous, "An improved process for preparation of Suzetrigine", Technical Disclosure Commons, ()
https://www.tdcommons.org/dpubs_series/12099