Abstract
This disclosure describes Bio-Architectural Morphogenesis, a conceptual framework in which an engineered, highly proliferative cell chassis is programmed to form load-bearing structures through externally guided morphogenesis and terminal biomineralization. It covers chassis selection tiers, separation of proliferation from invasiveness, positional-readout and boundary-triggered hardening modules, a layered biocontainment architecture, a two-compartment growth model with a diffusion-limited active layer showing that perfusion governs scale, a containment failure estimate, comparison of target material properties with bone and concrete, a hybrid hardening and self-repair design, environmental, ethical and regulatory considerations, and a staged validation roadmap.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Recommended Citation
Chiang Chong, Chen, "Bio-Architectural Morphogenesis: A Conceptual Framework for Programmable Living Structural Materials Using Engineered Proliferative Cell Chassis and Externally Guided Morphogenetic Networks", Technical Disclosure Commons, ()
https://www.tdcommons.org/dpubs_series/12014