Abstract
This document presents a study‑only, conceptual, open‑hardware systems design created for professional evaluation during the 2026 Andes hantavirus outbreak. It describes two independent research concepts:
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A multiplex nucleic‑acid detection research cartridge using chemical lysis, magnetic silica bead cleanup, isothermal amplification, and CRISPR‑Cas detection with triplex logic (ANDV S‑segment, pan‑hantavirus L‑segment, synthetic RNA internal control).
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A modular extracorporeal adsorption cartridge concept using TPMS gyroid geometry with a primary cytokine‑adsorption layer and an optional, highly speculative viral‑decoy layer.
This disclosure is not a medical device, not validated, and not intended for clinical use. No safety, efficacy, or performance is claimed. All biochemical, hemocompatibility, adsorption, and assay‑specific behaviors require independent evaluation by qualified professionals. The architecture is released under CERN‑OHL‑P to enable open scientific review and humanitarian research.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Recommended Citation
Caldwell, Michael Victor Mr., "Project Sentinel‑Andes Dual‑Platform Concept: A Study‑Only Open‑Hardware Architecture for Rapid ANDV Research Diagnostics and Extracorporeal Host‑Response Modulation Concepts", Technical Disclosure Commons, (May 13, 2026)
https://www.tdcommons.org/dpubs_series/10111