Abstract
Abstract: Disclosed is a bioadaptive extracorporeal hemofluidic envelope (GCI-300 platform) that conditions blood via low-shear, multi-pass flow using staged inertial enrichment, geometry-enforced rheological self-limiting, and near-wall magnetophoretic biasing. The device unifies three subsystems—inertial rheology envelope, enrichment corridor, and magnetophoretic guidance zone—within a compliant, pulsatile loop that maintains shear rates below 150 s⁻¹, bounded residence times, and hemocompatibility targets (e.g., plasma free Hb <20 mg/dL rise, βᵢ ≥0.85 bioinvisibility metric). Blood enters via impedance-matched inlet, undergoes Dean-flow near-wall enrichment in curved microchannels (50 µm height, 250–500 µm width, 1.5–4 mm radius), experiences distributed low-field magnetic bias without bulk trapping, and recirculates a fraction for cumulative gentle conditioning before reintegration. Gas-equilibrium membranes ensure pO₂/pCO₂ stability. Prototype geometry and bench protocol enable lab validation of enrichment vs. hemolysis, platelet activation, and complement effects per ISO 10993-4. Platform derivatives target cytokine bias, CTC/exosome handling, sepsis, and trauma support by swapping biasing matrices (magnetic, acoustic, affinity). All designs released under CERN-OHL-P for open development.
A bioadaptive extracorporeal hemofluidic envelope that conditions blood via low‑shear, multi‑pass flow using staged inertial enrichment,
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Recommended Citation
Caldwell, Michael Victor Mr., "GCI-300: Low-Shear Inertial-Magnetophoretic Blood Conditioning Envelope for Extracorporeal Therapy (CERN-OHL-P)", Technical Disclosure Commons, ()
https://www.tdcommons.org/dpubs_series/10053