Abstract
The present application relates to a process for preparation of the compound of Formula-5, a key intermediate in the production of Samidorphan. Samidorphan, also identified as 17-(cyclopropylmethyl)-4,14-dihydroxy-6-oxomorphinan-3-carboxamide or morphinan-3-carboxamide, 17-(cyclopropylmethyl)-4,14-dihydroxy-6-oxo, is represented by the structural formula-1.
Formula-1 Formula-5.
wherein n is 1, 2, 3, 4 or 5; R is hydrogen, methyl, and allyl.
The present invention also provides a process for the preparation of Samidorphan or its salts.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Recommended Citation
MSN Laboratories Private Limited, R&D Center; Srinivasan Thirumalai Rajan, Sagyam Rajeshwar Reddy, Bakthavachalam Ananthan, M Maniyarasan and Kansani Yadagiri., "A PROCESS FOR THE PREPARATION OF SAMIDORPHAN AND ITS INTERMEDIATES", Technical Disclosure Commons, (November 22, 2024)
https://www.tdcommons.org/dpubs_series/7589