Abstract
N-methyl-2-(4-nitrophenyl)ethanamine of Formula-1 or its salt and 1-(2-chloroethoxy)-4-nitrobenzene are the key intermediates in the preparation of N-[4-(2-{[2-(4-methane sulfonamidophenoxy)ethyl] (methyl)amino}ethyl)phenyl]methanesulfonamide, is also known as Dofetilide. Current invention provides a process for the preparation of N-methyl-2-(4-nitrophenyl)ethanamine of Formula-1 or its salt and 1-(2-chloroethoxy)-4-nitrobenzene of formula-2.
Formula-1 Formula-2.
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Recommended Citation
Srinivasan Thirumalai Rajan, Muppa Kishore Kumar, Mummadi Venkatesh, Bommidi Ramakrishna, Yallannagari Bhaskar Reddy; R&D Center, MSN Laboratories Private Limited; Hyderabad, India., "Process for the preparation of Dofetilide intermediates", Technical Disclosure Commons, (July 18, 2022)
https://www.tdcommons.org/dpubs_series/5262