Tapentadol hydrochloride of formula I, a centrally-acting analgesic compound, is chemically known as 3-[(1R,2R)-3-(dimethylamino)-1-ethyl-2methylpropyl]phenol monohydrochloride and marketed under the trade name Nucynta®. The present invention provides an alternative process for the preparation of Tapentadol hydrochloride.
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"Process for the preparation of Tapentadol hydrochloride", Technical Disclosure Commons, (March 14, 2022)